The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism

A loss of stromal caveolin-1 (Cav-1) in the tumor fibroblast compartment is associated with early tumor recurrence, lymphnode metastasis and tamoxifen-resistance, resulting in poor clinical outcome in breast cancer patients. Here, we have used Cav-1 (−/−) null mice as a pre-clinical model for this “...

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Autors principals: Pavlides, Stephanos, Tsirigos, Aristotelis, Migneco, Gemma, Whitaker-Menezes, Diana, Chiavarina, Barbara, Flomenberg, Neal, Frank, Philippe G, Casimiro, Mathew C, Wang, Chenguang, Pestell, Richard G, Martinez-Outschoorn, Ubaldo E, Howell, Anthony, Sotgia, Federica, Lisanti, Michael P
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047615/
https://ncbi.nlm.nih.gov/pubmed/20861672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.17.12721
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