The autophagic tumor stroma model of cancer or “battery-operated tumor growth”: A simple solution to the autophagy paradox

The role of autophagy in tumorigenesis is controversial. Both autophagy inhibitors (chloroquine) and autophagy promoters (rapamycin) block tumorigenesis by unknown mechanism(s). This is called the “Autophagy Paradox.” We have recently reported a simple solution to this paradox. We demonstrated that...

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Bibliographic Details
Main Authors: Martinez-Outschoorn, Ubaldo E, Whitaker-Menezes, Diana, Pavlides, Stephanos, Chiavarina, Barbara, Bonuccelli, Gloria, Trimmer, Casey, Tsirigos, Aristotelis, Migneco, Gemma, Witkiewicz, Agnieszka K, Balliet, Renee, Mercier, Isabelle, Wang, Chengwang, Flomenberg, Neal, Howell, Anthony, Lin, Zhao, Caro, Jaime, Pestell, Richard G, Sotgia, Federica, Lisanti, Michael P
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2010
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055183/
https://ncbi.nlm.nih.gov/pubmed/21051947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.21.13817
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