The autophagic tumor stroma model of cancer or “battery-operated tumor growth”: A simple solution to the autophagy paradox

The role of autophagy in tumorigenesis is controversial. Both autophagy inhibitors (chloroquine) and autophagy promoters (rapamycin) block tumorigenesis by unknown mechanism(s). This is called the “Autophagy Paradox.” We have recently reported a simple solution to this paradox. We demonstrated that...

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Detalhes bibliográficos
Main Authors: Martinez-Outschoorn, Ubaldo E, Whitaker-Menezes, Diana, Pavlides, Stephanos, Chiavarina, Barbara, Bonuccelli, Gloria, Trimmer, Casey, Tsirigos, Aristotelis, Migneco, Gemma, Witkiewicz, Agnieszka K, Balliet, Renee, Mercier, Isabelle, Wang, Chengwang, Flomenberg, Neal, Howell, Anthony, Lin, Zhao, Caro, Jaime, Pestell, Richard G, Sotgia, Federica, Lisanti, Michael P
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055183/
https://ncbi.nlm.nih.gov/pubmed/21051947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.21.13817
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