Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

Loss of stromal fibroblast caveolin-1 (Cav-1) is a powerful single independent predictor of poor prognosis in human breast cancer patients, and is associated with early tumor recurrence, lymph node metastasis and tamoxifen-resistance. We developed a novel co-culture system to understand the mechanis...

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Detalhes bibliográficos
Main Authors: Martinez-Outschoorn, Ubaldo E, Balliet, Renee M, Rivadeneira, Dayana B, Chiavarina, Barbara, Pavlides, Stephanos, Wang, Chenguang, Whitaker-Menezes, Diana, Daumer, Kristin M, Lin, Zhao, Witkiewicz, Agnieszka K, Flomenberg, Neal, Howell, Anthony, Pestell, Richard G, Knudsen, Erik S, Sotgia, Federica, Lisanti, Michael P
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041164/
https://ncbi.nlm.nih.gov/pubmed/20814239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.16.12553
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