Ketone bodies and two-compartment tumor metabolism: Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells

We have previously suggested that ketone body metabolism is critical for tumor progression and metastasis. Here, using a co-culture system employing human breast cancer cells (MCF7) and hTERT-immortalized fibroblasts, we provide new evidence to directly support this hypothesis. More specifically, we...

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Main Authors: Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Whitaker-Menezes, Diana, Howell, Anthony, Lisanti, Michael P., Sotgia, Federica
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507491/
https://ncbi.nlm.nih.gov/pubmed/23082721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.22136
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