Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

Previously, we proposed a new paradigm to explain the compartment-specific role of autophagy in tumor metabolism. In this model, autophagy and mitochondrial dysfunction in the tumor stroma promotes cellular catabolism, which results in the production of recycled nutrients. These chemical building bl...

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Detalhes bibliográficos
Main Authors: Salem, Ahmed F., Whitaker-Menezes, Diana, Lin, Zhao, Martinez-Outschoorn, Ubaldo E., Tanowitz, Herbert B., Al-Zoubi, Mazhar Salim, Howell, Anthony, Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404881/
https://ncbi.nlm.nih.gov/pubmed/22722266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20920
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