Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis

The role of PPARγ in cancer therapy is controversial, with studies showing either pro-tumorigenic or antineoplastic effects. This debate is very clinically relevant, because PPARγ agonists are used as antidiabetic drugs. Here, we evaluated if the effects of PPARγ on tumorigenesis are determined by t...

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Detalhes bibliográficos
Main Authors: Avena, Paola, Anselmo, Wanda, Whitaker-Menezes, Diana, Wang, Chenguang, Pestell, Richard G., Lamb, Rebecca S., Hulit, James, Casaburi, Ivan, Andò, Sebastiano, Martinez-Outschoorn, Ubaldo E., Lisanti, Michael P., Sotgia, Federica
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674064/
https://ncbi.nlm.nih.gov/pubmed/23574724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24289
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