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Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery

Metabolic coupling, between mitochondria in cancer cells and catabolism in stromal fibroblasts, promotes tumor growth, recurrence, metastasis, and predicts anticancer drug resistance. Catabolic fibroblasts donate the necessary fuels (such as L-lactate, ketones, glutamine, other amino acids, and fatt...

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Hlavní autoři: Lisanti, Michael P, Martinez-Outschoorn, Ubaldo E, Sotgia, Federica
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899185/
https://ncbi.nlm.nih.gov/pubmed/23860382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25695
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