Understanding the metabolic basis of drug resistance: Therapeutic induction of the Warburg effect kills cancer cells

Previously, we identified a form of epithelial-stromal metabolic coupling, in which cancer cells induce aerobic glycolysis in adjacent stromal fibroblasts, via oxidative stress, driving autophagy and mitophagy. In turn, these cancer-associated fibroblasts provide recycled nutrients to epithelial can...

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Main Authors: Martinez-Outschoorn, Ubaldo E, Lin, Zhao, Ko, Ying-Hui, Goldberg, Allison F, Flomenberg, Neal, Wang, Chenguang, Pavlides, Stephanos, Pestell, Richard G, Howell, Anthony, Sotgia, Federica, Lisanti, Michael P
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180190/
https://ncbi.nlm.nih.gov/pubmed/21768775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.15.16584
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