Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

Recently, using a co-culture system, we demonstrated that MCF7 epithelial cancer cells induce oxidative stress in adjacent cancer-associated fibroblasts, resulting in the autophagic/lysosomal degradation of stromal caveolin-1 (Cav-1). However, the detailed signaling mechanism(s) underlying this proc...

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Главные авторы: Martinez-Outschoorn, Ubaldo E, Trimmer, Casey, Lin, Zhao, Whitaker-Menezes, Diana, Chiavarina, Barbara, Zhou, Jie, Wang, Chengwang, Pavlides, Stephanos, Martinez-Cantarin, Maria P, Capozza, Franco, Witkiewicz, Agnieszka K, Flomenberg, Neal, Howell, Anthony, Pestell, Richard G, Caro, Jaime, Lisanti, Michael P, Sotgia, Federica
Формат: Artigo
Язык:Inglês
Опубликовано: Landes Bioscience 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047617/
https://ncbi.nlm.nih.gov/pubmed/20855962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.17.12928
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