Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control

Glioblastoma multiforme (GBM) is notoriously resistant to treatment. Therefore, new treatment strategies are urgently needed. ATM elicits the DNA damage response (DDR), which confers cellular radioresistance; thus, targeting the DDR with an ATM inhibitior (ATMi) is very attractive. Herein, we show t...

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Main Authors: Golding, Sarah E, Rosenberg, Elizabeth, Adams, Bret R, Wignarajah, Shayalini, Beckta, Jason M, O'Connor, Mark J, Valerie, Kristoffer
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335919/
https://ncbi.nlm.nih.gov/pubmed/22370485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.6.19576
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