Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control

Glioblastoma multiforme (GBM) is notoriously resistant to treatment. Therefore, new treatment strategies are urgently needed. ATM elicits the DNA damage response (DDR), which confers cellular radioresistance; thus, targeting the DDR with an ATM inhibitior (ATMi) is very attractive. Herein, we show t...

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Bibliographische Detailangaben
Hauptverfasser: Golding, Sarah E, Rosenberg, Elizabeth, Adams, Bret R, Wignarajah, Shayalini, Beckta, Jason M, O'Connor, Mark J, Valerie, Kristoffer
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2012
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335919/
https://ncbi.nlm.nih.gov/pubmed/22370485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.6.19576
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