Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

Ataxia telangiectasia (A-T) mutated (ATM) is critical for cell cycle checkpoints and DNA repair. Thus, specific small molecule inhibitors targeting ATM could perhaps be developed into efficient radiosensitizers. Recently, a specific inhibitor of the ATM kinase, KU-55933, was shown to radiosensitize...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Golding, Sarah E., Rosenberg, Elizabeth, Valerie, Nicholas, Hussaini, Isa, Frigerio, Mark, Cockcroft, Xiaoling F., Chong, Wei Yee, Hummersone, Marc, Rigoreau, Laurent, Menear, Keith A., O’Connor, Mark, Povirk, Lawrence F., van Meter, Timothy, Valerie, Kristoffer
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761990/
https://ncbi.nlm.nih.gov/pubmed/19808981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0519
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires