Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

Ataxia telangiectasia (A-T) mutated (ATM) is critical for cell cycle checkpoints and DNA repair. Thus, specific small molecule inhibitors targeting ATM could perhaps be developed into efficient radiosensitizers. Recently, a specific inhibitor of the ATM kinase, KU-55933, was shown to radiosensitize...

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Autores principales: Golding, Sarah E., Rosenberg, Elizabeth, Valerie, Nicholas, Hussaini, Isa, Frigerio, Mark, Cockcroft, Xiaoling F., Chong, Wei Yee, Hummersone, Marc, Rigoreau, Laurent, Menear, Keith A., O’Connor, Mark, Povirk, Lawrence F., van Meter, Timothy, Valerie, Kristoffer
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761990/
https://ncbi.nlm.nih.gov/pubmed/19808981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0519
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