ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells

We recently demonstrated that human embryonic stem cells (hESCs) utilize homologous recombination repair (HRR) as primary means of double-strand break (DSB) repair. We now show that hESCs also use nonhomologous end joining (NHEJ). NHEJ kinetics were several-fold slower in hESCs and neural progenitor...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Adams, Bret R., Hawkins, Amy J., Povirk, Lawrence F., Valerie, Kristoffer
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2010
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984607/
https://ncbi.nlm.nih.gov/pubmed/20844317
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk