ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells

We recently demonstrated that human embryonic stem cells (hESCs) utilize homologous recombination repair (HRR) as primary means of double-strand break (DSB) repair. We now show that hESCs also use nonhomologous end joining (NHEJ). NHEJ kinetics were several-fold slower in hESCs and neural progenitor...

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Главные авторы: Adams, Bret R., Hawkins, Amy J., Povirk, Lawrence F., Valerie, Kristoffer
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2010
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984607/
https://ncbi.nlm.nih.gov/pubmed/20844317
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