Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control

Glioblastoma multiforme (GBM) is notoriously resistant to treatment. Therefore, new treatment strategies are urgently needed. ATM elicits the DNA damage response (DDR), which confers cellular radioresistance; thus, targeting the DDR with an ATM inhibitior (ATMi) is very attractive. Herein, we show t...

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Main Authors: Golding, Sarah E, Rosenberg, Elizabeth, Adams, Bret R, Wignarajah, Shayalini, Beckta, Jason M, O'Connor, Mark J, Valerie, Kristoffer
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335919/
https://ncbi.nlm.nih.gov/pubmed/22370485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.6.19576
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