Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control

Glioblastoma multiforme (GBM) is notoriously resistant to treatment. Therefore, new treatment strategies are urgently needed. ATM elicits the DNA damage response (DDR), which confers cellular radioresistance; thus, targeting the DDR with an ATM inhibitior (ATMi) is very attractive. Herein, we show t...

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Bibliografiset tiedot
Päätekijät: Golding, Sarah E, Rosenberg, Elizabeth, Adams, Bret R, Wignarajah, Shayalini, Beckta, Jason M, O'Connor, Mark J, Valerie, Kristoffer
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Landes Bioscience 2012
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Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335919/
https://ncbi.nlm.nih.gov/pubmed/22370485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.6.19576
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