COMPOUND HETEROZYGOUS LOSS OF Ext1 AND Ext2 IS SUFFICIENT FOR FORMATION OF MULTIPLE EXOSTOSES IN POSTNATAL MOUSE LONG BONES IN MICE

Multiple Hereditary Exostoses (MHE) syndrome is caused by haploinsufficiency in Golgi-associated heparan sulfate polymerases EXT1 or EXT2 and is characterized by formation of exostoses next to growing long bones and other skeletal elements. Recent mouse studies have indicated that formation of stere...

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Autores principales: Zak, Beverly M., Schuksz, Manuela, Koyama, Eiki, Mundy, Christina, Wells, Daniel E., Yamaguchi, Yu, Pacifici, Maurizio, Esko, Jeffrey D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335264/
https://ncbi.nlm.nih.gov/pubmed/21310272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2011.02.001
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