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Mice deficient in Ext2 lack heparan sulfate and develop exostoses
Hereditary multiple exostoses (HME) is a genetically heterogeneous human disease characterized by the development of bony outgrowths near the ends of long bones. HME results from mutations in EXT1 and EXT2, genes that encode glycosyltransferases that synthesize heparan sulfate chains. To study the r...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2767329/ https://ncbi.nlm.nih.gov/pubmed/16236767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.02088 |
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