Identification and Characterization of Small Molecule Antagonists of pRb Inactivation by Viral Oncoproteins

The retinoblastoma protein pRb is essential for regulating many cellular activities through its binding and inhibition of E2F transcription activators, and pRb inactivation leads to many cancers. pRb activity can be perturbed by viral oncoproteins including human papillomavirus (HPV) that share an L...

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Autores principales: Fera, Daniela, Schultz, David C., Hodawadekar, Santosh, Reichman, Melvin, Donover, Preston Scott, Melvin, Jason, Troutman, Scott, Kissil, Joseph, Huryn, Donna M., Marmorstein, Ronen
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334872/
https://ncbi.nlm.nih.gov/pubmed/22520758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.03.007
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