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Identification and Characterization of Small Molecule Antagonists of pRb Inactivation by Viral Oncoproteins
The retinoblastoma protein pRb is essential for regulating many cellular activities through its binding and inhibition of E2F transcription activators, and pRb inactivation leads to many cancers. pRb activity can be perturbed by viral oncoproteins including human papillomavirus (HPV) that share an L...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3334872/ https://ncbi.nlm.nih.gov/pubmed/22520758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.03.007 |
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