Identification and Characterization of Small Molecule Antagonists of pRb Inactivation by Viral Oncoproteins

The retinoblastoma protein pRb is essential for regulating many cellular activities through its binding and inhibition of E2F transcription activators, and pRb inactivation leads to many cancers. pRb activity can be perturbed by viral oncoproteins including human papillomavirus (HPV) that share an L...

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Hauptverfasser: Fera, Daniela, Schultz, David C., Hodawadekar, Santosh, Reichman, Melvin, Donover, Preston Scott, Melvin, Jason, Troutman, Scott, Kissil, Joseph, Huryn, Donna M., Marmorstein, Ronen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334872/
https://ncbi.nlm.nih.gov/pubmed/22520758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.03.007
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