Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer

BACKGROUND: Structural rearrangements form a major class of somatic variation in cancer genomes. Local chromosome shattering, termed chromothripsis, is a mechanism proposed to be the cause of clustered chromosomal rearrangements and was recently described to occur in a small percentage of tumors. Th...

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Main Authors: Kloosterman, Wigard P, Hoogstraat, Marlous, Paling, Oscar, Tavakoli-Yaraki, Masoumeh, Renkens, Ivo, Vermaat, Joost S, van Roosmalen, Markus J, van Lieshout, Stef, Nijman, Isaac J, Roessingh, Wijnand, van 't Slot, Ruben, van de Belt, José, Guryev, Victor, Koudijs, Marco, Voest, Emile, Cuppen, Edwin
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2011
נושאים:
Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3333773/
https://ncbi.nlm.nih.gov/pubmed/22014273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2011-12-10-r103
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