Genomic and transcriptomic plasticity in treatment-naïve ovarian cancer

Intra-tumor heterogeneity is a hallmark of many cancers and may lead to therapy resistance or interfere with personalized treatment strategies. Here, we combined topographic mapping of somatic breakpoints and transcriptional profiling to probe intra-tumor heterogeneity of treatment-naïve stage IIIC/...

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Main Authors: Hoogstraat, Marlous, de Pagter, Mirjam S., Cirkel, Geert A., van Roosmalen, Markus J., Harkins, Timothy T., Duran, Karen, Kreeftmeijer, Jennifer, Renkens, Ivo, Witteveen, Petronella O., Lee, Clarence C., Nijman, Isaac J., Guy, Tanisha, van ’t Slot, Ruben, Jonges, Trudy N., Lolkema, Martijn P., Koudijs, Marco J., Zweemer, Ronald P., Voest, Emile E., Cuppen, Edwin, Kloosterman, Wigard P.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912411/
https://ncbi.nlm.nih.gov/pubmed/24221193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.161026.113
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