Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

Biochemical, epidemiological, and genetic findings demonstrate a link between cholesterol levels, processing of the amyloid precursor protein (APP), and Alzheimer's disease. In the present report, we identify the α-secretase ADAM 10 (a disintegrin and metalloprotease) as a major target of the choles...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kojro, Elzbieta, Gimpl, Gerald, Lammich, Sven, März, Winfried, Fahrenholz, Falk
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33296/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11309494/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.081612998
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