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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
Biochemical, epidemiological, and genetic findings demonstrate a link between cholesterol levels, processing of the amyloid precursor protein (APP), and Alzheimer's disease. In the present report, we identify the α-secretase ADAM 10 (a disintegrin and metalloprotease) as a major target of the c...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33296/ https://ncbi.nlm.nih.gov/pubmed/11309494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081612998 |
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