Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
Biochemical, epidemiological, and genetic findings demonstrate a link between cholesterol levels, processing of the amyloid precursor protein (APP), and Alzheimer's disease. In the present report, we identify the α-secretase ADAM 10 (a disintegrin and metalloprotease) as a major target of the choles...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2001
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33296/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11309494/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.081612998 |
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