Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

Biochemical, epidemiological, and genetic findings demonstrate a link between cholesterol levels, processing of the amyloid precursor protein (APP), and Alzheimer's disease. In the present report, we identify the α-secretase ADAM 10 (a disintegrin and metalloprotease) as a major target of the c...

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Detaylı Bibliyografya
Asıl Yazarlar: Kojro, Elzbieta, Gimpl, Gerald, Lammich, Sven, März, Winfried, Fahrenholz, Falk
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2001
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC33296/
https://ncbi.nlm.nih.gov/pubmed/11309494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081612998
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