Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing

Microsomal triglyceride transfer protein (Mtp) inhibitors represent a novel therapeutic approach to lower circulating LDL cholesterol, although therapeutic development has been hindered by the observed increase in hepatic triglycerides and liver steatosis following treatment. Here, we used small int...

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Bibliographische Detailangaben
Hauptverfasser: Tep, Samnang, Mihaila, Radu, Freeman, Alexander, Pickering, Victoria, Huynh, Felicia, Tadin-Strapps, Marija, Stracks, Allison, Hubbard, Brian, Caldwell, Jeremy, Flanagan, W. Michael, Kuklin, Nelly A., Ason, Brandon
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329385/
https://ncbi.nlm.nih.gov/pubmed/22355095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M021063
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