Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2

Drug combinations can improve the control of diseases involving redundant and highly regulated pathways. Validating a multi-target therapy early in drug development remains difficult. Small interfering RNAs (siRNAs) are routinely used to selectively silence a target of interest. Owing to the ease of...

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Bibliographic Details
Published in:Mol Ther Nucleic Acids
Main Authors: Mihaila, Radu, Ruhela, Dipali, Galinski, Beverly, Card, Ananda, Cancilla, Mark, Shadel, Timothy, Kang, Jing, Tep, Samnang, Wei, Jie, Haas, R. Matthew, Caldwell, Jeremy, Flanagan, W. Michael, Kuklin, Nelly, Cherkaev, Elena, Ason, Brandon
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463220/
https://ncbi.nlm.nih.gov/pubmed/30991218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.03.004
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