Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA

Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and currently are the leading systems for in vivo delivery. Here, we propose the use of an ordinary differential equation (ODE)-based model as a...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Mihaila, Radu, Ruhela, Dipali, Keough, Edward, Cherkaev, Elena, Chang, Silvia, Galinski, Beverly, Bartz, René, Brown, Duncan, Howell, Bonnie, Cunningham, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415968/
https://ncbi.nlm.nih.gov/pubmed/28624200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.04.003
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