Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA

Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and currently are the leading systems for in vivo delivery. Here, we propose the use of an ordinary differential equation (ODE)-based model as a...

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Bibliografske podrobnosti
izdano v:Mol Ther Nucleic Acids
Main Authors: Mihaila, Radu, Ruhela, Dipali, Keough, Edward, Cherkaev, Elena, Chang, Silvia, Galinski, Beverly, Bartz, René, Brown, Duncan, Howell, Bonnie, Cunningham, James J.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2017
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415968/
https://ncbi.nlm.nih.gov/pubmed/28624200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.04.003
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