Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA

Lipid nanoparticles (LNPs) have been used to successfully deliver small interfering RNAs (siRNAs) to target cells in both preclinical and clinical studies and currently are the leading systems for in vivo delivery. Here, we propose the use of an ordinary differential equation (ODE)-based model as a...

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Detalles Bibliográficos
Publicado en:Mol Ther Nucleic Acids
Main Authors: Mihaila, Radu, Ruhela, Dipali, Keough, Edward, Cherkaev, Elena, Chang, Silvia, Galinski, Beverly, Bartz, René, Brown, Duncan, Howell, Bonnie, Cunningham, James J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415968/
https://ncbi.nlm.nih.gov/pubmed/28624200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.04.003
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