siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids

Increased serum apolipoprotein (apo)B and associated LDL levels are well-correlated with an increased risk of coronary disease. ApoE(–/–) and low density lipoprotein receptor (LDLr)(–/–) mice have been extensively used for studies of coronary atherosclerosis. These animals show atherosclerotic lesio...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Tadin-Strapps, Marija, Peterson, Laurence B., Cumiskey, Anne-Marie, Rosa, Raymond L., Mendoza, Vivienne Halili, Castro-Perez, Jose, Puig, Oscar, Zhang, Liwen, Strapps, Walter R., Yendluri, Satyasri, Andrews, Lori, Pickering, Victoria, Rice, Julie, Luo, Lily, Chen, Zhu, Tep, Samnang, Ason, Brandon, Somers, Elizabeth Polizzi, Sachs, Alan B., Bartz, Steven R., Tian, Jenny, Chin, Jayne, Hubbard, Brian K., Wong, Kenny K., Mitnaul, Lyndon J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090230/
https://ncbi.nlm.nih.gov/pubmed/21398511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M012872
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