siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids

Increased serum apolipoprotein (apo)B and associated LDL levels are well-correlated with an increased risk of coronary disease. ApoE(–/–) and low density lipoprotein receptor (LDLr)(–/–) mice have been extensively used for studies of coronary atherosclerosis. These animals show atherosclerotic lesio...

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Detalhes bibliográficos
Main Authors: Tadin-Strapps, Marija, Peterson, Laurence B., Cumiskey, Anne-Marie, Rosa, Raymond L., Mendoza, Vivienne Halili, Castro-Perez, Jose, Puig, Oscar, Zhang, Liwen, Strapps, Walter R., Yendluri, Satyasri, Andrews, Lori, Pickering, Victoria, Rice, Julie, Luo, Lily, Chen, Zhu, Tep, Samnang, Ason, Brandon, Somers, Elizabeth Polizzi, Sachs, Alan B., Bartz, Steven R., Tian, Jenny, Chin, Jayne, Hubbard, Brian K., Wong, Kenny K., Mitnaul, Lyndon J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090230/
https://ncbi.nlm.nih.gov/pubmed/21398511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M012872
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