The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing

The use of short interfering RNAs (siRNA) in animals for target validation or as potential therapeutics is hindered by the short physical half-life when delivered as unencapsulated material and in turn the short active half-life of siRNAs in vivo. Here we demonstrate that the character of the two 3′...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Strapps, Walter R., Pickering, Victoria, Muiru, Gladys T., Rice, Julie, Orsborn, Stacey, Polisky, Barry A., Sachs, Alan, Bartz, Steven R.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919711/
https://ncbi.nlm.nih.gov/pubmed/20360048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq206
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker