The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing

The use of short interfering RNAs (siRNA) in animals for target validation or as potential therapeutics is hindered by the short physical half-life when delivered as unencapsulated material and in turn the short active half-life of siRNAs in vivo. Here we demonstrate that the character of the two 3′...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Strapps, Walter R., Pickering, Victoria, Muiru, Gladys T., Rice, Julie, Orsborn, Stacey, Polisky, Barry A., Sachs, Alan, Bartz, Steven R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2010
Ämnen:
Molecular Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919711/
https://ncbi.nlm.nih.gov/pubmed/20360048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq206
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk