The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing

The use of short interfering RNAs (siRNA) in animals for target validation or as potential therapeutics is hindered by the short physical half-life when delivered as unencapsulated material and in turn the short active half-life of siRNAs in vivo. Here we demonstrate that the character of the two 3′...

Full description

Saved in:
Bibliographic Details
Main Authors: Strapps, Walter R., Pickering, Victoria, Muiru, Gladys T., Rice, Julie, Orsborn, Stacey, Polisky, Barry A., Sachs, Alan, Bartz, Steven R.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919711/
https://ncbi.nlm.nih.gov/pubmed/20360048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq206
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items