Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth

Short interfering RNAs (siRNAs) are a valuable tool for gene silencing with applications in both target validation and therapeutics. Many advances have recently been made to improve potency and specificity, and reduce toxicity and immunostimulation. However, siRNA delivery to a variety of tissues re...

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Bibliografiske detaljer
Udgivet i:Mol Ther Nucleic Acids
Main Authors: Khan, Tayeba, Weber, Hans, DiMuzio, Jillian, Matter, Andrea, Dogdas, Belma, Shah, Tosha, Thankappan, Anil, Disa, Jyoti, Jadhav, Vasant, Lubbers, Laura, Sepp-Lorenzino, Laura, Strapps, Walter R, Tadin-Strapps, Marija
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023400/
https://ncbi.nlm.nih.gov/pubmed/27483025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.55
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