Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit

The present study aimed at establishing feasibility of delivering short interfering RNA (siRNA) to target the coagulation cascade in rat and rabbit, two commonly used species for studying thrombosis and hemostasis. siRNAs that produced over 90% mRNA knockdown of rat plasma prekallikrein and rabbit F...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Chen, Zhu, Luo, Bin, Cai, Tian-Quan, Thankappan, Anil, Xu, Yiming, Wu, Weizhen, DiMuzio, Jillian, Lifsted, Traci, DiPietro, Marty, Disa, Jyoti, Ng, Bruce, Leander, Karen, Clark, Seth, Hoos, Lizbeth, Zhou, Yuchen, Jochnowitz, Nina, Jachec, Christine, Szczerba, Peter, Gindy, Marian E., Strapps, Walter, Sepp-Lorenzino, Laura, Seiffert, Dietmar A., Lubbers, Laura, Tadin-Strapps, Marija
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345307/
https://ncbi.nlm.nih.gov/pubmed/25625614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.75
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