Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation

Clinical application of siRNA-based therapeutics outside of the liver has been hindered by the inefficient delivery of siRNA effector molecules into extra-hepatic organs and cells of interest. To understand the parameters that enable RNAi activity in vivo, it is necessary to develop a systematic app...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: Ng, Bruce, Cash-Mason, Tanesha, Wang, Yi, Seitzer, Jessica, Burchard, Julja, Brown, Duncan, Dudkin, Vadim, Davide, Joseph, Jadhav, Vasant, Sepp-Lorenzino, Laura, Cejas, Pedro J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426712/
https://ncbi.nlm.nih.gov/pubmed/30901578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.02.013
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