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miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression

ATP-binding cassette transporter A1 (ABCA1) is a cholesterol transporter that transfers excess cellular cholesterol onto lipid-poor apolipoproteins. Given its critical role in cholesterol homeostasis, ABCA1 has been studied as a therapeutic target for Alzheimer’s disease. Transcriptional regulation...

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Autors principals: Kim, Jaekwang, Yoon, Hyejin, Ramírez, Cristina M., Lee, Sang-Mi, Hoe, Hyang-Sook, Fernández-Hernando, Carlos, Kim, Jungsu
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328628/
https://ncbi.nlm.nih.gov/pubmed/22119192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2011.11.010
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