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Specific Disruption of Abca1 Targeting Largely Mimics the Effects of miR-33 Knockout on Macrophage Cholesterol Efflux and Atherosclerotic Plaque Development

RATIONALE: Inhibition of miR-33 reduces atherosclerotic plaque burden, but miR-33 deficient mice are predisposed to the development of obesity and metabolic dysfunction. The pro-atherogenic effects of miR-33 are thought to be in large part due to its repression of macrophage cholesterol efflux, thro...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Price, Nathan L., Rotllan, Noemi, Zhang, Xinbo, Canfrán-Duque, Alberto, Nottoli, Timothy, Suarez, Yajaira, Fernández-Hernando, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417928/
https://ncbi.nlm.nih.gov/pubmed/30707082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.314415
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