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miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression
ATP-binding cassette transporter A1 (ABCA1) is a cholesterol transporter that transfers excess cellular cholesterol onto lipid-poor apolipoproteins. Given its critical role in cholesterol homeostasis, ABCA1 has been studied as a therapeutic target for Alzheimer’s disease. Transcriptional regulation...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3328628/ https://ncbi.nlm.nih.gov/pubmed/22119192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2011.11.010 |
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