Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-α/β

To understand how virulent mycobacteria subvert host immunity and establish disease, we examined the differential response of mice to infection with various human outbreak Mycobacterium tuberculosis clinical isolates. One clinical isolate, HN878, was found to be hypervirulent, as demonstrated by unu...

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Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Manca, Claudia, Tsenova, Liana, Bergtold, Amy, Freeman, Sherry, Tovey, Michael, Musser, James M., Barry, Clifton E., Freedman, Victoria H., Kaplan, Gilla
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2001
Teme:	Biological Sciences
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11320211/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091096998
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