Immunopathologic Effects of Tumor Necrosis Factor Alpha in Murine Mycobacterial Infection Are Dose Dependent

In experimental mycobacterial infection, tumor necrosis factor alpha (TNF-α) is required for control of bacillary growth and the protective granulomatous response, but may cause immunopathology. To directly examine the positive and detrimental effects of this cytokine, a murine model was used in whi...

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Autori principali: Bekker, Linda-Gail, Moreira, Andre L., Bergtold, Amy, Freeman, Sherry, Ryffel, Bernard, Kaplan, Gilla
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
Soggetti:
Bacterial Infections
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC97804/
https://ncbi.nlm.nih.gov/pubmed/11083819
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