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Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-α/β

To understand how virulent mycobacteria subvert host immunity and establish disease, we examined the differential response of mice to infection with various human outbreak Mycobacterium tuberculosis clinical isolates. One clinical isolate, HN878, was found to be hypervirulent, as demonstrated by unu...

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Detaylı Bibliyografya
Asıl Yazarlar: Manca, Claudia, Tsenova, Liana, Bergtold, Amy, Freeman, Sherry, Tovey, Michael, Musser, James M., Barry, Clifton E., Freedman, Victoria H., Kaplan, Gilla
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2001
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC33285/
https://ncbi.nlm.nih.gov/pubmed/11320211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091096998
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