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Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-α/β

To understand how virulent mycobacteria subvert host immunity and establish disease, we examined the differential response of mice to infection with various human outbreak Mycobacterium tuberculosis clinical isolates. One clinical isolate, HN878, was found to be hypervirulent, as demonstrated by unu...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Manca, Claudia, Tsenova, Liana, Bergtold, Amy, Freeman, Sherry, Tovey, Michael, Musser, James M., Barry, Clifton E., Freedman, Victoria H., Kaplan, Gilla
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33285/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11320211/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091096998
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