Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-α/β

To understand how virulent mycobacteria subvert host immunity and establish disease, we examined the differential response of mice to infection with various human outbreak Mycobacterium tuberculosis clinical isolates. One clinical isolate, HN878, was found to be hypervirulent, as demonstrated by unu...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Manca, Claudia, Tsenova, Liana, Bergtold, Amy, Freeman, Sherry, Tovey, Michael, Musser, James M., Barry, Clifton E., Freedman, Victoria H., Kaplan, Gilla
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2001
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC33285/
https://ncbi.nlm.nih.gov/pubmed/11320211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091096998
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk