Genetic Loss of Insulin Receptors Worsens Cardiac Efficiency in Diabetes

AIMS: To determine the contribution of insulin signaling versus systemic metabolism to metabolic and mitochondrial alterations in type 1 diabetic hearts and test the hypothesis that antecedent mitochondrial dysfunction contributes to impaired cardiac efficiency (CE) in diabetes. METHODS AND RESULTS:...

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Detalhes bibliográficos
Main Authors: Bugger, Heiko, Riehle, Christian, Jaishy, Bharat, Wende, Adam R., Tuinei, Joseph, Chen, Dong, Soto, Jamie, Pires, Karla M., Boudina, Sihem, Theobald, Heather A., Luptak, Ivan, Wayment, Benjamin, Wang, Xiaohui, Litwin, Sheldon E., Weimer, Bart C., Abel, E. Dale
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327790/
https://ncbi.nlm.nih.gov/pubmed/22342406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.02.001
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