Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome

Cardiac dysfunction in obesity is associated with mitochondrial dysfunction, oxidative stress and altered insulin sensitivity. Whether oxidative stress directly contributes to myocardial insulin resistance remains to be determined. This study tested the hypothesis that ROS scavenging will improve mi...

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Pubblicato in:J Mol Cell Cardiol
Autori principali: Ilkun, Olesya, Wilde, Nicole, Tunei, Joseph, Pires, Karla M.P., Zhu, Yi, Bugger, Heiko, Soto, Jamie, Wayment, Benjamin, Olsen, Curtis, Litwin, Sheldon E., Abel, E. Dale
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530070/
https://ncbi.nlm.nih.gov/pubmed/26004364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.05.012
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