HD mouse models reveal clear deficits in learning to perform a simple instrumental response

Mouse models of Huntington’s disease (HD) were trained to acquire one of two simple instrumental responses (a lever press or a nosepoke) to obtain food reinforcement. Animals from several HD strains revealed apparently progressive deficits in this task, being significantly less able than littermate...

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Main Authors: Oakeshott, Stephen, Port, Russell G, Cummins-Sutphen, Jane, Watson-Johnson, Judy, Ramboz, Sylvie, Park, Larry, Howland, David, Brunner, Dani
格式: Artigo
語言:Inglês
出版: Public Library of Science 2011
主題:
Huntington Disease
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327146/
https://ncbi.nlm.nih.gov/pubmed/22512000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.RRN1282
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