ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the GroEL Chaperonin

The chaperonin GroEL assists the folding of nascent or stress-denatured polypeptides by actions of binding and encapsulation. ATP binding initiates a series of conformational changes triggering the association of the cochaperonin GroES, followed by further large movements that eject the substrate po...

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Autori principali: Clare, Daniel K., Vasishtan, Daven, Stagg, Scott, Quispe, Joel, Farr, George W., Topf, Maya, Horwich, Arthur L., Saibil, Helen R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326522/
https://ncbi.nlm.nih.gov/pubmed/22445172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.02.047
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