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ATP-triggered ADP release from the asymmetric chaperonin GroEL/GroES/ADP(7) is not the rate-limiting step of the GroEL/GroES reaction cycle
The GroEL/GroES protein folding chamber is formed and dissociated by ATP binding and hydrolysis. ATP hydrolysis in the GroES-bound (cis) ring gates entry of ATP into the opposite unoccupied trans ring, which allosterically ejects cis ligands. While earlier studies suggested that hydrolysis of cis AT...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2849271/ https://ncbi.nlm.nih.gov/pubmed/20083109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.01.021 |
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