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GroEL/GroES cycling: ATP binds to an open ring before substrate protein favoring protein binding and production of the native state

The GroEL/GroES reaction cycle involves steps of ATP and polypeptide binding to an open GroEL ring before the GroES encapsulation step that triggers productive folding in a sequestered chamber. The physiological order of addition of ATP and nonnative polypeptide, typically to the open trans ring of...

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Autori principali: Tyagi, Navneet K., Fenton, Wayne A., Horwich, Arthur L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777187/
https://ncbi.nlm.nih.gov/pubmed/19915138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911556106
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