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Topologies of a Substrate Protein Bound to the Chaperonin GroEL

The chaperonin GroEL assists polypeptide folding through sequential steps of binding nonnative protein in the central cavity of an open ring, via hydrophobic surfaces of its apical domains, followed by encapsulation in a hydrophilic cavity. To examine the binding state, we have classified a large da...

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Detalhes bibliográficos
Main Authors: Elad, Nadav, Farr, George W., Clare, Daniel K., Orlova, Elena V., Horwich, Arthur L., Saibil, Helen R.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885994/
https://ncbi.nlm.nih.gov/pubmed/17499047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.04.004
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